Subject to your strategy there are various possible booking flow setups:
1) Classic room category sales with attribute-based selling
In this setting the standard categories determine the lowest selling product and price point. Room Feature Combinations (RFCs) and Virtual Products (ERFCs) are only offered through Most Popular and when using the configurator. However, no product will be sold below the lowest available Standard Room Product (MRFC).
2) Personalized selling
In this setting the standard categories will only be sold under Lowest Price. Otherwise, only RFCs and ERFCs will be sold through the ISE. This makes your own website completely non-comparable from other channels and allows full automated personalization.
3) Bait Shopper setting with attribute-based selling
This setting is similar to the classic room category sales with attribute-based pricing, however used if the property wants to attract more traffic to its own website by rock-bottom pricing. This works in combination of creating a Virtual Product (ERFC) and pricing it lower than any other room product, hence the Lowest Price point will be much more aggressive than any other Standard Product.